Twelve fire engines and 81 firefighters and officers were called to a fire at an industrial estate in East Duck Lees Lane in Ponders End.
Part of the ground floor, first floor and roof of a warehouse were damaged by the fire.
The Brigade was called at 0913 and the fire was under control at 1159. Fire crews from Enfield, Chingford, Edmonton, Woodford, Tottenham, Southgate and other surrounding fire stations attended the scene.
Crews will remain at the scene throughout the night damping down hotspots.
The cause of the fire is under investigation.