Premier League newcomers Watford suffered a League Cup upset in a 1-0 loss at Preston North End while five-times champions Aston Villa overcame plucky Notts County 5-3 after extra time to reach the third round on Tuesday.
Marnick Vermijl’s eighth minute strike gave Championship side Preston victory over Watford at Deepdale with the defender on-loan from Sheffield Wednesday netting from close range.
Scott Sinclair struck a hat-trick for Villa, who had to level three times against their fourth-tier opponents, and Jermain Defoe also got a treble to help Sunderland chalk up a 6-3 win over Exeter City at The Stadium of Light.
Leicester City and Newcastle United were also among the goals with 4-1 wins away to third-tier Bury and at home to Northampton Town respectively, while Bournemouth thrashed another bottom division team Hartlepool 4-0 away.
Top-flight Stoke City, West Bromwich Albion and Crystal Palace were also taken to extra time before prevailing in their second-round clashes with lower league opponents.
Stoke won 8-7 on penalties at fourth-tier Luton Town after the game finished 1-1 in 120 minutes and West Brom prevailed 5-3 over third-tier Port Vale in a shootout following a 0-0 draw.
Palace eventually triumphed 4-1 after an extra 30 minutes having been held 1-1 at home by third-tier Shrewsbury Town.
The other two Premier League sides in action on Tuesday went through with Swansea City beating bottom division York City 3-0 while Norwich City edged second-tier Rotherham United 2-1 away.
Teenage striker Bright Enobakhare made a dream debut by scoring for Wolves in a 2-1 Capital One Cup success against Barnet at Molineux.
Enobakhare, 17, who was handed a two-year professional deal last month, fired Wolves into the lead after just three minutes.
Wolves doubled their advantage in the 58th minute through another exciting teenager, 18-year-old on-loan Liverpool winger Sheyi Ojo who scored his first goal for the club.
Barnet spent much of the game on the defensive with goalkeeper Jamie Stephens pulling off some smart saves, but their never-say-die attitude earned its reward in the 76th minute when Bira Dembele reduced the arrears.
That looked to have sealed Wolves’ success but battling Barnet set up a nervy finale for the hosts when Dembele forced the ball home from close range after Elliot Johnson had floated the ball into the area.
Fulham will be hoping to transfer their cup form to the League after an impressive 3-0 win over Sheffield United with their goals all coming in the second half from their captain Ross McCormack two one a penalty when he was tugged back after attempting a 62nd minute bicycle kick.
Frenchman Dembele was rewarded after several missed chances with a goal right on the final whistle with a fierce low shot from 20 yards out.
Former Manchester United trainee Ryan Tunnicliffe hit the crossbar after 12 minutes and was very impressive in the Fulham midfield.
The Capital One Cup Round 3 draw has been made, with the 16 fixtures due to be played in the week commencing 21st September 2015.
Norwich City v West Bromwich Albion
Hull City v Swansea City
Leicester City v West Ham United
Aston Villa v Birmingham City
Tottenham Hotspur v Arsenal
Manchester United v Ipswich Town
Liverpool v Carlisle United
Crystal Palace v Charlton Athletic
Fulham v Stoke City
Sunderland v Manchester City
Newcastle United v Sheffield Wednesday
Reading v Barnsley or Everton
Preston North End v Bournemouth
Walsall v Chelsea
Milton Keynes Dons v Southampton