Ten fire engines and 72 firefighters and officers were called to a fire at a pub in Chalton Street, Euston.
Around half of the roof and second floor of the building were damaged. There were no reports of any injuries.
Station Manager Steve Chesson, who was at the scene, said: “The pub was open and in use at the time of the fire and a number of people left the building before the Brigade arrived.”
The Brigade’s 999 Control Officers took 18 calls to the fire.
The Brigade was called at 2006 and the fire was under control at 2128. Fire crews from Soho, Islington, Kentish Town, Shoreditch, Paddington and surrounding fire stations were at the scene.
The cause of the fire is under investigation.