Eric Rubin, Deputy Assistant Secretary in the Bureau of European and Eurasian Affairs at the US State Department, will visit Athens and Cyprus from 17-21 October.
A State Department official said the talks with the Greek and Cypriot leadership will concern a wide aspect of bilateral and regional issues.
Rubin has visited Turkey on a recent trip, it was further clarified.
He undertook office in July, replacing Tina Kaidanow.